• GeneralVincent@lemmy.world
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    6 days ago

    Yup, I made a bad generalization. My bad, and to be clear I’m not a doctor or anything.

    Some SSRIs may have an interaction with grapefruit. But grapefruit interacts with different medications differently, and it’s not based on the class of medication, it’s med specific.

    e.g. Sertraline (Zoloft) is an SSRI and is listed as having an interaction with grapefruit

    https://en.wikipedia.org/wiki/Grapefruit–drug_interactions

    Eta: thanks for calling that out, I’ve learned some interesting things, for example;

    Ketamine: After drinking 200 mL of grapefruit juice daily for five days, the overall absorption of orally ingested ketamine was increased three-fold compared to the control group in a clinical trial. The peak blood ketamine concentration was increased over two-fold.

    • sem@piefed.blahaj.zone
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      5 days ago

      That is so weird. Here is the study: https://pubmed.ncbi.nlm.nih.gov/10890261/

      It was only n=5 but my layperson understanding is that the results were significant.

      Either I’ve never noticed a grapefruit warning (and at one time I read the documentation fully) or Sertraline doesn’t come with one…