

Outside of security patches there probably won’t be the latest version of apps available, so the software you use can be out of date and you will have to wiat for new features that have been implemented. Flatpak mostly solves this for gui user-level apps, but it’s not set up by default and can require tinkering with permissions to fix some issues.
If you have new hardware it might not work well with the kernel that comes installed, but you can enable backports and get a newer one.
Practically half the linux exo-system is built on top of debian, so you can get a different distro built on debian but with better default experience or custom guis for certain tasks like managing drivers, so people you can save time and not have to dive into terminal commands following how-to guides for various things.
According to this post, once these projects move to bootc, they are going to get rid of layering and allow you to just dnf install what you need.
Seems like it will get rid of a lot of pain points.